Libraries based on an isolated human immunoglobulin G1 (IgG1) constant domain 2 (CH2) have been previously diversified by random mutagenesis.However, native isolated CH2 is not very stable and the generation of many mutations could lead to an increase in immunogenicity.Recently, we demonstrated that engineering an additional disulfide bond and remo
The paper indicates the importance of spatial planning as a TROUSERS SPLIT SUIT EMERSON specific instrument for the protection and management of World Heritage sites in Serbia.The paper analyses the obligations set forth in the international and national documents and legislation relevant for spatial planning, on the one hand, and World Heritage pr
Abstract: Fragrances may cause allergic contact dermatitis.Data on patients who were patch tested, between 2000 and 2015, with fragrance allergens IMMUNE 7 included in the Brazilian baseline series (balsam of Peru, colophony and fragrance mix I), were collected and analyzed.Of these patients, 258 (13.8%) were positive for fragrance markers, 9.8% be
The availability of enormous numbers of mobile applications (apps) is driving demand for the means to Glucosamine search for, recommend, and manage apps.Existing search engines provide basic search functionalities that enable users to find apps by issuing query keywords; however, the ranking of search results does not always satisfy the expectation